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Test Code DIA Diazepam and Metabolites, Serum

Reporting Name

Diazepam and metabolites, S

Useful For

Assessing compliance

 

Monitoring for appropriate therapeutic level

 

Assessing diazepam toxicity

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum Red


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Red top (Serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

Therapeutic concentrations

Diazepam: Not established

Diazepam and Nordiazepam: 100-2,500 ng/mL

 

Cutoff concentrations by liquid chromatography tandem mass spectrometry:

Diazepam: 10 ng/mL

Nordiazepam: 10 ng/mL

Oxazepam: 10 ng/mL

Temazepam: 10 ng/mL

Day(s) Performed

Wednesday

CPT Code Information

80299

LOINC Code Information

Test ID Test Order Name Order LOINC Value
DIA Diazepam and metabolites, S 49044-1

 

Result ID Test Result Name Result LOINC Value
8629 Diazepam 3548-5
2475 Nordiazepam 3537-8
2459 Diazepam and Nordiazepam 16757-7
622868 Oxazepam 3886-9
622869 Temazepam 10343-2

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

Report Available

3 to 7 days