Home
HelpTest Code HCYSS Homocysteine, Total, Serum
Reporting Name
Homocysteine, Total, SUseful For
An aid for screening patients suspected of having an inherited disorder of methionine metabolism including:
-Cystathionine beta-synthase deficiency (homocystinuria)
-Methylenetetrahydrofolate reductase deficiency and its thermolabile variants:
-Methionine synthase deficiency
-Cobalamin (Cbl) metabolism
-Combined methyl-Cbl and adenosyl-Cbl deficiencies: Cbl C2, Cbl D2, and Cbl F3 deficiencies
-Methyl-Cbl specific deficiencies: Cbl D-Var1, Cbl E, and Cbl G deficiencies
-Transcobalamin II deficiency
-Adenosylhomocysteinase deficiency
-Glycine N-methyltransferase deficiency
-Methionine adenosyltransferase I/III deficiency
Screening and monitoring patients suspected of, or confirmed with, an inherited disorder of methionine metabolism using serum specimens
Evaluating individuals with suspected deficiency of vitamin B12 or folate
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
SerumNecessary Information
Patient's age and sex are required.
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Within 4 hours of collection, centrifuge and aliquot serum into plastic vial.
Specimen Minimum Volume
0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 28 days |
| Frozen | 309 days | |
| Ambient | 28 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Special Instructions
Reference Values
Total Homocysteine (nmol/mL)
|
Age |
Female |
Male |
|
0-11 months |
3.1-8.3 |
3.2-9.7 |
|
12-23 months |
3.2-8.3 |
3.3-9.6 |
|
24-35 months |
3.2-8.2 |
3.3-9.6 |
|
3 years |
3.2-8.2 |
3.3-9.6 |
|
4 years |
3.3-8.2 |
3.4-9.5 |
|
5 years |
3.4-8.1 |
3.5-9.4 |
|
6 years |
3.5-8.1 |
3.6-9.4 |
|
7 years |
3.5-8.1 |
3.7-9.4 |
|
8 years |
3.6-8.2 |
3.8-9.3 |
|
9 years |
3.7-8.2 |
3.9-9.4 |
|
10 years |
3.8-8.3 |
4.1-9.4 |
|
11 years |
3.9-8.4 |
4.3-9.4 |
|
12 years |
3.9-8.6 |
4.4-9.5 |
|
13 years |
4.0-8.7 |
4.6-9.6 |
|
14 years |
4.1-8.8 |
4.8-9.7 |
|
15 years |
4.2-8.9 |
5.0-9.8 |
|
16 years |
4.2-9.1 |
5.2-9.9 |
|
17 years |
4.3-9.2 |
5.4-10.0 |
|
18 years |
4.3-9.3 |
5.6-10.1 |
|
19 years |
4.4-9.5 |
5.7-10.3 |
|
20 years |
4.4-9.6 |
5.9-10.5 |
|
21 years |
4.4-9.8 |
6.0-10.6 |
|
22 years |
4.4-9.9 |
6.1-10.8 |
|
23 years |
4.4-10.1 |
6.2-11.0 |
|
24 years |
4.4-10.3 |
6.2-11.1 |
|
25 years |
4.4-10.4 |
6.3-11.3 |
|
26 years |
4.4-10.6 |
6.3-11.4 |
|
27 years |
4.3-10.8 |
6.4-11.6 |
|
28 years |
4.3-11.0 |
6.4-11.7 |
|
29 years |
4.3-11.2 |
6.4-11.8 |
|
30 years |
4.3-11.4 |
6.4-11.9 |
|
31 years |
4.4-11.6 |
6.4-12.1 |
|
32 years |
4.4-11.8 |
6.4-12.2 |
|
33 years |
4.4-11.9 |
6.4-12.3 |
|
34 years |
4.5-12.1 |
6.4-12.4 |
|
35 years |
4.5-12.2 |
6.4-12.6 |
|
36 years |
4.6-12.4 |
6.4-12.8 |
|
37 years |
4.6-12.5 |
6.4-12.9 |
|
38 years |
4.7-12.7 |
6.4-13.1 |
|
39 years |
4.7-12.8 |
6.4-13.2 |
|
40 years |
4.8-13.0 |
6.5-13.4 |
|
41 years |
4.8-13.2 |
6.5-13.5 |
|
42 years |
4.8-13.4 |
6.5-13.7 |
|
43 years |
4.9-13.5 |
6.6-13.9 |
|
44 years |
4.9-13.7 |
6.6-14.0 |
|
45 years |
4.9-13.9 |
6.6-14.2 |
|
46 years |
4.9-14.0 |
6.7-14.4 |
|
47 years |
4.9-14.2 |
6.7-14.5 |
|
48 years |
5.0-14.3 |
6.8-14.7 |
|
49 years |
5.0-14.4 |
6.8-14.9 |
|
50 years |
5.0-14.5 |
6.8-15.0 |
|
51 years |
5.1-14.6 |
6.8-15.2 |
|
52 years |
5.1-14.7 |
6.9-15.4 |
|
53 years |
5.1-14.8 |
6.9-15.5 |
|
54 years |
5.2-14.9 |
6.9-15.6 |
|
55 years |
5.2-15.0 |
6.9-15.7 |
|
56 years |
5.3-15.0 |
6.9-15.8 |
|
57 years |
5.3-15.1 |
6.9-15.9 |
|
58 years |
5.3-15.2 |
6.9-16.0 |
|
59 years |
5.4-15.2 |
6.9-16.0 |
|
60 years |
5.4-15.3 |
6.9-16.1 |
|
61 years |
5.4-15.4 |
7.0-16.2 |
|
62 years |
5.5-15.4 |
7.0-16.2 |
|
63 years |
5.5-15.5 |
7.0-16.3 |
|
64 years |
5.6-15.5 |
7.1-16.3 |
|
65 years |
5.6-15.6 |
7.1-16.3 |
|
66 years |
5.7-15.6 |
7.1-16.3 |
|
67 years |
5.7-15.7 |
7.2-16.3 |
|
68 years |
5.8-15.7 |
7.2-16.3 |
|
69 years |
5.9-15.7 |
7.2-16.3 |
|
70 years |
6.0-15.8 |
7.3-16.3 |
|
71 years |
6.1-15.8 |
7.3-16.3 |
|
72 years |
6.2-15.8 |
7.3-16.3 |
|
73 years |
6.3-15.9 |
7.3-16.3 |
|
74 years |
6.4-15.9 |
7.3-16.3 |
|
75 years |
6.5-15.9 |
7.3-16.3 |
|
76 years |
6.6-15.9 |
7.3-16.3 |
|
77 years |
6.7-16.0 |
7.4-16.3 |
|
78 years |
6.8-16.0 |
7.4-16.3 |
|
79 years |
6.9-16.0 |
7.5-16.3 |
|
80 years |
7.0-16.0 |
7.5-16.3 |
|
81 years |
7.1-16.0 |
7.7-16.2 |
|
82 years |
7.2-16.0 |
7.8-16.2 |
|
83 years |
7.2-16.0 |
7.9-16.2 |
|
84 years |
7.3-16.0 |
8.0-16.2 |
|
85 years |
7.3-16.0 |
8.2-16.2 |
|
>85 years |
7.4-16.0 |
8.3-16.2 |
Day(s) Performed
Monday through Friday
CPT Code Information
83090
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| HCYSS | Homocysteine, Total, S | 13965-9 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 35836 | Homocysteine, Total, S | 13965-9 |