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Test Code MPSS Monoclonal Protein Study, Serum


Ordering Guidance


To monitor a patient with an established diagnosis of a monoclonal gammopathy, order PELO / M-Spike Follow-up, Serum.



Specimen Required


Patient Preparation: Fasting preferred, but not required

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Useful For

Diagnosis of monoclonal gammopathies, when used in conjunction with urine monoclonal studies

 

Monitoring patients with monoclonal gammopathies

 

Protein electrophoresis alone is not considered an adequate screen for monoclonal gammopathies.

Profile Information

Test ID Reporting Name Available Separately Always Performed
TPE Total Protein Yes, (order TP) Yes
ELP Protein Electrophoresis No Yes
IMFX Immunofixation Yes, (order IMFXO) Yes

Testing Algorithm

This test includes total protein, serum protein electrophoresis, and immunofixation. If a monoclonal light chain is detected in the absence of an associated monoclonal heavy chain, an immunofixation electrophoresis (IFE) specific for delta and epsilon chains is performed.

 

The following algorithms are available:

-Amyloidosis: Laboratory Approach to Diagnosis

-Multiple Myeloma: Laboratory Screening

Method Name

TPE: Colorimetric, Biuret

ELP: Agarose Gel Electrophoresis

IMFX, IFXED: Immunofixation

Reporting Name

Monoclonal Protein Study, S

Specimen Type

Serum

Specimen Minimum Volume

0.6 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Ambient  14 days
  Frozen  14 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

PROTEIN, TOTAL

≥1 year: 6.3-7.9 g/dL

Reference values have not been established for patients that are younger than 12 months of age.

 

PROTEIN ELECTROPHORESIS

Albumin: 3.4-4.7 g/dL

Alpha-1-globulin: 0.1-0.3 g/dL

Alpha-2-globulin: 0.6-1.0 g/dL

Beta-globulin: 0.7-1.2 g/dL

Gamma-globulin: 0.6-1.6 g/dL

M-Spike: 0.0 g/dL

An interpretive comment is provided with the report.

 

IMMUNOFIXATION

No monoclonal protein detected

 

IMMUNOFIXATION FLAG

Negative

Performing Laboratory

MCHS- La Crosse Lab

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

84155

84165

86334

86334-Immunofixation Delta and Epsilon (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MPSS Monoclonal Protein Study, S 24351-9

 

Result ID Test Result Name Result LOINC Value
TPE Total Protein 2885-2
2769 Albumin 2862-1
81653 Immunofixation 74665-1
606977 Flag, Immunofixation No LOINC Needed
2770 Alpha-1 Globulin 2865-4
2771 Alpha-2 Globulin 2868-8
2773 Beta-Globulin 2871-2
2774 Gamma-Globulin 2874-6
2785 A/G Ratio 44429-9
22308 M spike 33358-3
22309 M spike 33358-3
15254 Impression 49296-7

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IFXED Immunofixation Delta and Epsilon, S Yes No

Day(s) Performed

Tuesday, Thursday

Report Available

1 to 6 days